ABSTRACT
Despite evidence of cytokine gene variation in SARS-CoV-2 sickness is few, understanding the function of genetic polymorphisms in the course of respiratory infections may aid in the identification of possible andidates for future inquiry in SARS-CoV-2 patients. As a result, the study raises crucial issues about how cytokine gene polymorphisms may have a role in the severity of COVID-19 sickness. ARMS-PCR was used to detect genotype frequency data for the IL-1B SNP (rs 16944), (rs1143627). All data statistical analyses were performed using the Statistical Package for Social Science (SPSS 26).. shows the genotype distributions (frequencies) of the chosen IL-1B SNPs, rs16944 A/G and rs1143627 G/A, as well as their relationships with SARS-COV2 risk. Significant relationships between the rs16944 A/G and SARS-COV2 risk were found in the samples, The AG variant genotype (AG vs. AA) showed an adjusted OR of 1.0 (95 percent CI = 1.770 (0.935-0.353), P = 0.078*) when compared to the rs16944 AA genotype. There were no statistical differences in rs1143627 polymorphism between the two groups, and there was no evidence that rs1143627 may be associated with an increased risk of acquiring SARS-COV2 based on the results of the p value G (P = 0.167), G/A (P = 0.22), and G/G (P = 0.22). This was the first study to look at the rs1143627 polymorphism in relation to SARS-COV 2, therefore no previous research was published.first, second, and third level headings (first level heading). © 2023 Author(s).
ABSTRACT
Introduction the majority of individuals with coronavirus disease SARS-COV2 have mild to moderate illness that does not necessitate hospitalization. However, no research has been conducted to examine the progression of symptoms in Babylon province. Method, SPSS version 26 were used in analysis of data collected and revealing all possible correlation. Conclusion According to the findings, the majority of patients had low levels of oxygen 71(62.8%) of the time, whilst patients with normal levels 42(37.2%) of the time were in severe condition. Despite the fact that all SARS-COV-2 patients in this study had vital signs taken, it was discovered that more than half of them had SPo2 levels within the normal range, with a 150(64.3%) significantly different P-value (0.0001) 113 (48.5 %) of those with severe symptoms described the most severe symptoms, followed by moderate and mild symptoms. There was a high prevalence of chronic history, with 145 individuals (62 percent) having no history of chronic disease, diabetic patients (60%), and hypertension patients (28 percent) (12 %). The overall number of patients who required oxygen was 101 (43.3 %) less than the total number of patients who did not require oxygen. © 2022 ThinkBiotech LLC. All rights reserved.
ABSTRACT
A respiratory illness outbreak caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) began in China and spread to other nations. Typically, the real-time reverse transcriptase polymerase chain reaction of nasopharyngeal swabs has been utilized to confirm the clinical diagnosis. However, it is uncertain if the virus is found in specimens from other places, and therefore, possibly transmitted in methods other than respiratory droplets. Patients with coronavirus disease 2019 (COVID-19) were identified based on symptoms, and SARS-CoV-2 detection confirmed the diagnosis. Pharyngeal swabs were obtained from August to September 2020. Individuals with obtained samples based on clinical indications from hospitals in Marjan City and a public health laboratory in Babylon Province, Iraq, were included in this retrospective study. The findings of the clinical symptoms and their intensity were provided in the chart, which revealed that all indications were equal in both male and female patients, with no obvious differences, especially given that all patients' ages ranged from 30 to 70 years. High temperature, sore throat, and shortness of breath were shown to be the most common symptoms, in comparison to other symptoms in the chart.